Protein Details: Voltage-gated Potassium channel-interacting protein 4
Protein ID
ICDB_Pro_1249
Protein Name
Voltage-gated Potassium channel-interacting protein 4
Gene Name
KCNIP4; KCHIP4
Organism
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Length
250 amino acids
AlphaFoldDB
AF-Q8HYN7-F1-model_v4.pdb
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane
Sequence
MNVRRVESISAQLEEASSTGGFLYAQNSTKRSIKERLMKLLPCSAAKTSSPAIQNSVEDELEMATVRHRPEALELLEAQSKFTKKELQILYRGFKNECPSGVVNEETFKEIYSQFFPQGDSTTYAHFLFNAFDTDHNGAVSFEDFIKGLSILLRGTVQEKLNWAFNLYDINKDGYITKEEMLDIMKAIYDMMGKCTYPVLKEDAPRQHVETFFQKMDKNKDGVVTIDEFIESCQKDENIMRSMQLFENVI
PDB Structures
Ligand Binding
Binding Site
133;135;137;144;169;171;173;175;180;217;219;221;228
Disease
Location
DOI ID
RefSeq
XP_005554619.1 [Q8HYN7-1]